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M94A2914.TXT
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1994-10-25
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Document 2914
DOCN M94A2914
TI Intrathecal synthesis of anti gp120 V3 loop antibodies in HIV-infection.
DT 9412
AU Mata S; Lolli F; Pinto F; Colao MG; DeMajo E; Mecocci L; Brizzi M; Blanc
PL; Paci P; Mazzotta F; Department of Neurological Sciences, University
of Florence,; Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0213). Unique
Identifier : AIDSLINE ICA10/94369661
AB OBJECTIVE: The detection of CSF antibody against the V3 loop of HIVMN by
peptide ELISA has been recently reported in a high percentage of
patients (LUCEY DR et al., J. AIDS 1993, 6:994-1001). We re-evaluated
the occurence of intrathecal synthesis (ITS) of antibodies to the V3
loop of HIVMN. METHODS: We measured the antibodies to the HIV gp120 V3
loop (strain MN) in the cerebrospinal fluid and serum of 47 HIV infected
patients by peptide-ELISA. RESULTS: Antibodies to V3 were detected in
the serum of 94% and in the CSF of 78% of the patients. ITS of the
antibodies took place in only 30% of the patients and in low levels
(mean ratio of serum/CSF titers equal to 215). All patients presented
intrathecal synthesis of antibodies to gp 120 by Western blot.
CONCLUSION: Despite the ITS of antibodies to gp 120 in HIV infection,
the antibody response to the V3 loop is of much lower level and thus
constititute a basis for the defective immunoregulation of the virus in
the nervous system.
DE Cerebrospinal Fluid Proteins/*IMMUNOLOGY Comparative Study HIV
Antibodies/BIOSYNTHESIS/BLOOD/*CEREBROSPINAL FLUID HIV Envelope Protein
gp120/*IMMUNOLOGY HIV Infections/BLOOD/*CEREBROSPINAL FLUID/IMMUNOLOGY
HIV-1/*IMMUNOLOGY Peptide Fragments/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).